段晶晶 教授、博士生导师
研究方向:鞘脂代谢与衰老
主要荣誉及专业团队任职:国家级人才、省部级人才;中国老年学和老年医学会学会委员、中国营养学会转化医学会委员;人类衰老研究所PI
邮箱:duan.jingjing@ncu.edu.cn
课题组网站:
http://aging.ncu.edu.cn/kytd/49559.htm
https://jingjingduan.wixsite.com/duanlab
教育经历:
2014/08—2017/05 (美)哈佛大学,博士后,导师:David Clapham
2012/06—2014/08 (美)佐治亚理工大学,博士后,导师:Alfred Merrill
2008/09—2012/03 (日)京都大学,博士研究生/博士,导师:平田 孝
2007/09—2008/08 (日)长崎大学,研究生,导师:小田 达也
2001/09—2008/07 大连海洋大学,生命科学与技术学院,学士、硕士,导师:李霞
工作经历:
2018/09—今 南昌大学 教授
2018/06—2018/08 美国 埃默里大学医学院 Research Fellow
2017/05—2018/06 美国 霍华德休斯医学研究所 Research Associate
2014/08—2017/05 美国 哈佛大学/波士顿儿童医院 博士后 Research Fellow
2012/06—2014/08 美国 佐治亚理工大学 博士后 Research Faculty
执教课程:
本科生课程:《生物化学》、《免疫学》
研究生课程:《生物学前沿进展》、《科技论文写作》
主持课题项目:
1、 国家自然科学基金面上项目“鞘脂代谢对离子通道TRPM4/7的功能调控的分子机制研究” 2020.01-2023.12(在研)
2、 国家自然科学基金面上项目“新型1-脱氧鞘脂通过干预细胞膜功能及下游S1P信号通路调节衰老的机制”2022.01-2025.12(在研)
3、 国家级人才项目“天然鞘脂与人类健康”(在研)
主要学术贡献及奖励:
2013 “Future Leader in Nutrigenomics”, NUL, NE, USA
2013 Japan Oil Chemists' Society -8th J. Oleo Sci. Impact Award, Japan
2012 “Topics Award” of Japan Society for Bioscience Biotechnology and Agrochemistry
代表性学术论文:
Hu Z, Chen Y, Wang X, Deng Y, Wang X, Li S, Ding X, Duan J. Accumulation of Fatty Acylated Fusarium Toxin 2-Amino-14,16-dimethyloctadecan-3-ol, a Class of Novel 1-Deoxysphingolipid Analogues, during Food Storage. J Agric Food Chem. 2022 Apr 27;70(16):5151-5158.(通讯作者)
Song X, Li J, Tian M, Zhu H, Hu X, Zhang Y, Cao Y, Ye H, McCormick PJ, Zeng B, Fu Y#, Duan J#, Zhang J#. Cryo-EM structure of mouse TRPML2 in lipid nanodiscs. J Biol Chem. 2022 Feb;298(2):101487. doi: 10.1016/j.jbc.2021.101487. (共同通讯作者)
Ding, R. B.; Liu, L.; Hu, Z. Y.; Wu, A. D.; Zhu, H. Y.; Ruan, Q. X.; Qiu, H. M.; Hong, Y. J.; Hu, B. J.; Duan, J. J., In vivo noninvasive and rapid evaluation of pearls in freshwater mussels based on micro-CT. Aquaculture 2021, 534. (通讯作者)
Wan, J., Li, J., Bandyopadhyay, S., Kelly, S. L., Xiang, Y., Zhang, J., Merrill, A. H., Jr., Duan, J., Analysis of 1-Deoxysphingoid Bases and Their N-Acyl Metabolites and Exploration of Their Occurrence in Some Food Materials. J Agric Food Chem 2019, 67 (46), 12953-12961.(通讯作者)
Duan, J., Li, J., Chen, G. L., Ge, Y., Liu, J., Xie, K., Peng, X., Zhou, W., Zhong, J., Zhang, Y., Xu, J., Xue, C., Liang, B., Zhu, L., Liu, W., Zhang, C., Tian, X. L., Wang, J., Clapham, D. E., Zeng, B., Li, Z., Zhang, J., Cryo-EM structure of TRPC5 at 2.8-A resolution reveals unique and conserved structural elements essential for channel function. Science Advances 2019, 5 (7), eaaw7935.
Duan, J., Li, J., Zeng, B., Chen, G. L., Peng, X. G., Zhang, Y. X., Wang, J. B., Clapham, D. E., Li, Z. L., Zhang, J., Structure of the mouse TRPC4 ion channel. Nature Communications 2018, 9(1):3102.
Duan, J., Li, Z. L., Li, J., Hulse, R. E., Santa-Cruz, A., Valinsky, W. C., Abiria, S. A., Krapivinsky, G., Zhang, J., Clapham, D. E., Structure of the mammalian TRPM7, a magnesium channel required during embryonic development. P Natl Acad Sci USA 2018, 115 (35), Eb201-Eb210.
Duan, J., Li, Z. L., Li, J., Santa-Cruz, A., Sanchez-Martinez, S., Zhang, J., Clapham, D. E., Structure of full-length human TRPM4. P Natl Acad Sci USA 2018, 115 (10), 2377-2382.
Duan, J. and Merrill, A.H. 1-Deoxysphingolipids encountered exogenously and made de novo: dangerous mysteries inside an enigma. J Biol Chem 2015 290, 15380-15389.
Duan, J., Ishida, M., Aida, K., Tsuduki, T., Zhang, J., Manabe, Y., Hirata, T. and Sugawara, T. . Dietary Cerebroside from Sea Cucumber (Stichopus japonicus): Absorption and Effects on Skin Barrier and Cecal Short-Chain Fatty Acids. J Agric Food Chem 2016 64, 7014–7021. (共同通讯作者)